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美國(guó)GeneGo?
GeneGo是為系統(tǒng)生物學(xué)中的數(shù)據(jù)挖掘應(yīng)用提供領(lǐng)先的化學(xué)信息學(xué)和生物信息學(xué)軟件解決方案的供應(yīng)商。公司的產(chǎn)品為從基因組學(xué)和代謝組學(xué)到蛋白質(zhì)組學(xué)和毒理基因組學(xué)的研 究與實(shí)驗(yàn)提供支持。MetaBase是GeneGo專業(yè)研制的哺乳動(dòng)物生物學(xué)與藥物化學(xué)數(shù)據(jù)庫(kù)，是目前在系統(tǒng)生物學(xué)領(lǐng)域覆蓋范圍最廣的數(shù)據(jù)庫(kù)。 MetaCore是公司的旗艦產(chǎn)品，為系統(tǒng)生物學(xué)研究中的通路分析和生物標(biāo)記物發(fā)現(xiàn)提供了完整的數(shù)據(jù)挖掘工具套件。

MetaDrug是GeneGo的系統(tǒng)藥理學(xué)平臺(tái)，在結(jié)合化學(xué)信息學(xué)和生物信息學(xué)基礎(chǔ)上，該平臺(tái)為轉(zhuǎn)化醫(yī)學(xué)、免疫學(xué)、炎癥與腫瘤研究提供了有力的預(yù)測(cè)工具。GeneGo產(chǎn) 品的客戶以知名大學(xué)和大型生命科學(xué)公司為主，他們遍及歐洲、亞洲和美國(guó)。通過(guò)與來(lái)自業(yè)界與學(xué)術(shù)界的研究者的廣泛合作，GeneGo致力于推動(dòng)生物信息學(xué)軟件的應(yīng)用，為加快發(fā)現(xiàn)新療法與生物標(biāo)記物提供強(qiáng)力支持。

GeneGo的工具和數(shù)據(jù)庫(kù)能夠幫助研究人員挖掘和定義各種高通量實(shí)驗(yàn)數(shù)據(jù)背后潛在的生物學(xué)意義，了解小分子藥物在人體組織中的作用。GeneGo公司還為生命科學(xué)研究和藥物開發(fā)的不同應(yīng)用范圍提供了全方位的解決方案，包括從臨床前的疾病發(fā)現(xiàn)到臨床治療中的NCE應(yīng)用，其范圍涵蓋了生物學(xué)與化學(xué)的所有方面。
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GeneGo is a leading provider of data mining & analysis solutions in systems biology. Our data mining tools and databases help to capture and define the underlying biology behind different types of high-throughput experimental data and understand the effects of small molecule drug compounds in human tissues. We provide systems biology solutions for a full range of applications in life science research and drug development, from pre-clinical discovery and NCE applications to clinical trials, covering all aspects of biology and chemistry.

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GeneGo’s flagship bioinformatics product in systems biology, MetaCore?, assists scientists in three main areas:

Drug target selection and validation;
Identification of biomarkers for specific disease states and
Patient profiling in clinical trials.
Whether the data derives from microarray gene expression studies, SNPs, metabolic profiles or high content screening (HCS) assays, MetaCore’s sophisticated analytical data mining tools enable the identification and prioritization of the most relevant pathways, networks and cellular processes affected by the condition. The MetaCore? suite works on the proprietary content of MetaBase?, GeneGo’s manually curated database of mammalian biology and medicinal chemistry. MetaBase? is the most comprehensive knowledge base available today in systems biology. It allows scientists to network virtually all known human signaling and metabolic reactions and to understand how bioactive compounds interact with and affect these networks based on experimental data. Our second product, MetaDrug?, is GeneGo’s fully assembled systems pharmacology platform that can be used to predict human metabolites, toxicity and mode of action of novel small molecule compounds.

GeneGo’s customer list for our systems biology product offerings includes the largest life science companies and leading universities and research institutions in the US, Europe and Asia. We partner with a broad group of investigators in academy and industry with matching data analysis technologies, content databases and data analysis projects.

Tatiana Nikolskaya, Ph.D., previously a molecular biologist at the University of Chicago, founded GeneGo in 2000. Based on her extensive wet lab background, Dr. Nikolskaya defined the immediate utility of GeneGo technology for bench researchers as the key objective. The GeneGo multi-disciplinary team includes experts in molecular and systems biology, metabolism, graph theory, human diseases and medicinal chemistry. The company employs over 90 scientists and software developers at the corporate headquarters in St. Joseph, MI, with offices in San Diego, CA and in Moscow, Russia. GeneGo is a private company owned by the management team. Its sales revenues and technology grants fund ongoing research and product development for bioinformatics applications within systems biology.

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